Symbicort Alternatives: Effective Options for Asthma and COPD

When you rely on Symbicort, a combination inhaler with budesonide (a corticosteroid) and formoterol (a long-acting beta agonist) used to control asthma and COPD. Also known as budesonide/formoterol, it helps reduce inflammation and open airways—but not everyone can tolerate it. Some people face side effects like throat irritation, hoarseness, or even increased heart rate. Others need a cheaper option, or their insurance won’t cover it. That’s where other combination inhalers, like Advair, Dulera, and Breo, which also pair a corticosteroid with a long-acting bronchodilator come in. These aren’t just backups—they’re proven alternatives that work for many of the same conditions.

If Symbicort isn’t working for you, it’s not about giving up. It’s about finding what fits your body. Fluticasone/salmeterol (Advair), for example, has been studied in over 10,000 patients with COPD and showed similar lung function improvements. Mometasone/formoterol (Dulera), on the other hand, may cause less oral thrush because of its delivery system. And for those who need lower doses or are sensitive to formoterol, budesonide with albuterol (like Airsupra) offers a fast-acting rescue option paired with maintenance control. Even single-agent inhalers, like using a corticosteroid alone (e.g., Flovent) with a separate short-acting bronchodilator (e.g., albuterol), can be a smart, flexible approach if your symptoms aren’t severe.

What’s clear from real-world use is that switching isn’t random. It’s based on your symptoms, side effects, cost, and how your body responds. People with COPD often need longer-lasting control, while asthma patients might prioritize quick relief. Some switch because of cost—Symbicort can run over $300 without insurance, while generics like fluticasone/salmeterol can drop below $50. Others switch after developing thrush or tremors. The key is working with your doctor to test one option at a time and track how you feel. You’re not stuck with what you were first prescribed. Below, you’ll find real stories and comparisons from people who’ve tried different inhalers, from the most common alternatives to lesser-known options. No fluff. Just what works, what doesn’t, and what to ask your provider next.